Disease Applications
Breast Cancer
Breast
cancer affects over 194,000 women and men in the United States each
year, with over 40,000 succumbing to the disease yearly.
Worldwide, about 519,000 people die from the disease each year.
HER2/neu
expressing breast cancer cells have been indentified in about one third
of patients and are associated with more aggressive tumors, shorter
relapse time from treatment and poorer overall survival.
Etubics
is developing a therapeutic breast cancer vaccine targeting
HER2/neu cancer cells. Published pre-clinical studies indicate a
cell-mediated immune response against HER2/neu which result in
reduction of tumor size and control of progression. The
immunotherapeutic product has also been shown to prevent tumor
establishment in pre-clinical studies.